As a University of Applied Learning, SIT works closely with industry in our research pursuits. Our research staff will have the opportunity to be equipped with applied research skill sets that are relevant to industry demands while working on research projects in SIT.
Job Purpose
The Research Fellow will lead the development of a Surface-Enhanced Raman Spectroscopy (SERS) biosensor platform for rapid detection of microbial bioburden in biopharmaceutical cleaning validation processes. The role involves aptamer discovery, nanomaterial-based SERS sensor development, and integration with microfluidic systems for real-time monitoring of cleaning validation washout fluids. Opportunities to contribute to patent filings, translational research, and commercialization pathways will be available.
Key Responsibilities
Technical Responsibilities
- Design and screen high-affinity ssDNA aptamers targeting environmental microorganisms listed in the US Pharmacopeia.
- Develop nanoparticle-based SERS substrates (Ag/Au nanoclusters) for enhanced Raman signal detection.
- Design and fabricate microfluidic sensing interfaces for continuous monitoring of cleaning validation fluids.
- Perform sensor validation using Raman spectroscopy, microbial cultures, and cleaning validation samples.
- Develop data analysis pipelines for Raman spectral classification, potentially integrating machine learning methods.
Research & Project Responsibilities
- Plan and execute experimental workflows to achieve project milestones.
- Lead prototype development and performance optimization of the SERS biosensor system.
- Communicate research outcomes through technical reports, conference presentations, and scientific publications.
- Collaborate with industry partners and interdisciplinary research teams where applicable.
Operational Responsibilities
- Conduct risk assessments and ensure compliance with Work Safety and Health (WSH) regulations.
- Manage procurement of specialized equipment and research consumables.
Mentorship
- Mentor research engineers, graduate students, and undergraduate researchers.
- Contribute to training activities within the research group.
Others
- To communicate in any relevant internal or external stakeholders to ensure project deliverables are met.
- Any ad-hoc duties assigned by Supervisor.
Job Requirements
Essential
- PhD in Bioengineering, Chemical Engineering, Materials Science, Nanotechnology, Analytical Chemistry, or related fields.
- Strong publication record in biosensors, nanomaterials, Raman spectroscopy, or microfluidics.
- Demonstrated experience in nanoparticle-based biosensor development or SERS sensing platforms.
- Proficiency in CAD software (e.g., SolidWorks) for microfluidic device design.
- Experience with Raman spectroscopy instrumentation and spectral data analysis.
Preferred
- Experience in microfluidic chip fabrication (soft lithography, PDMS, or micro-machining).
- Experience with aptamer selection or molecular recognition elements.
- Experience applying machine learning to spectral data (Raman, LC–MS, or similar).
- Experience working on translational or industry-linked research projects.